Nance-Major House and Store is a historic home and country store located across from the Charles City County Courthouse in Charles City, Virginia, United States. The Nance-Major Store, built around 1872, is a two-story, three-bay, gable-front frame building supported by a brick pier foundation. The Nance-Major House was built about 1869, and is an L-shaped, 2+1⁄2-story, post-and-beam-frame dwelling covered with painted horizontal weatherboard. It features a steeply pitched, front-gabled roof and a two-story, three-bay, full-width porch. Additional structures on the property include a contributing smokehouse, a grain barn, a tool shed, and a garage. The store was in operation from 1874 until 1963.